Date of Graduation

Spring 5-16-2014

Document Type

Thesis

Degree Name

Master of Science in Chemistry

College/School

College of Arts and Sciences

Department/Program

Chemistry

First Advisor

Dr. Lawrence Margerum

Second Advisor

Dr. William Melaugh

Third Advisor

Dr. Ryan West

Abstract

Chemosensors are created through a series of reaction steps on controlled pore class (CPG) and terminate with a Cu2+ metal binding site. Each monolayer of reactant insures that the metal binding site exposed to solution would serve as an indicator displacement assay (IDA) sensor. The purpose of this research is to create a molecular sensor with a high density of terminal metal sites to quantify bidentate substrates. To accomplish this, each synthetic step of the sensor is examined in order to test the effects of new linkers, ligands, and variously sized dendrimers to see if small structural changes could promote a higher density of terminal metal sites. For linkers, the results show that CDI and TESPSA are comparable in functionality, whereas the ligand, lysine-NTA outperforms an amino-functionalized terpyridine in metal chelation. For dendrimers, higher generation dendrimers lead to more terminal Cu2+ metal binding sites than lower generation dendrimers.

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