Document Type
Poster
Publication Date
2023
Department
Chemistry
Abstract
Antimicrobial Peptides (AMPs) are novel therapeutic agents that play important roles in the innate immune system with its ability to kill gram-positive and gram-negative bacteria. Antibiotics are losing their efficacy, thus requiring a larger dose of medicine for treatment resulting in the increase of antibiotic resistance. AMPs are an attractive approach for exploration due to their broad-spectrum activity and ease of synthesis. Furthermore, fewer bacteria have developed resistance to AMPs. Several AMPs have demonstrated increased antimicrobial activity with metal ions, like Zn(II) and Cu(II) binding to the peptide. In this study, we performed the purification of Calcitermin through high-performance liquid chromatography (HPLC) and will be analyzing the metal-binding thermodynamics through isothermal titration calorimetry (ITC).
Recommended Citation
Aviles-Sandoval, Maria G. and Stevenson, Michael, "Quantifying Metal Interactions with the Antimicrobial Peptide Calcitermin" (2023). Featured Student Work. 11.
https://repository.usfca.edu/studentwork/11
Included in
Amino Acids, Peptides, and Proteins Commons, Inorganic Chemicals Commons, Medical Biochemistry Commons
Comments
This poster was produced for the American Chemical Society National Conference Fall 2023. This work is a part of the Stevenson Lab at USF and funded by Dr. Ron Najafi (Emery Pharma Summer Research Fellowship 2023).