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Current research related to the subject matter of business informatics reflects divergent orientations that are fundamentally about representing, analyzing, and designing services or processes or work systems or enterprises. After summarizing those four orientations and citing typical exemplars, this paper identifies a variety of paths toward greater integration between different orientations within business informatics. It identifies central topics for each orientation along with areas in which each orientation provides ideas that complement other orientations and reveal possible synergies. Both the approach for identifying potential synergies and the proposed synergies themselves could encourage greater integration within business informatics.